ParkinsonCanadaV1, Main, Exploration, bibRecord, 002D44

Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: Their relation to disease-compensatory mechanisms

Identifieur interne : 002D44 ( Main/Exploration ); précédent : 002D43; suivant : 002D45

Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: Their relation to disease-compensatory mechanisms

Auteurs : Vesna Sossi [Canada] ; Raul De La Fuente-Fernandez [Canada] ; James E. Holden [Canada] ; Michael Schulzer [Canada] ; Thomas J. Ruth [États-Unis] ; Jon Stoessl [Canada]

Source :

Journal of cerebral blood flow and metabolism [ 0271-678X ] ; 2004.

RBID : Pascal:04-0472982

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Dopamine, Turnover, Système nerveux pathologie, Tomoscintigraphie, Cérébrovasculaire pathologie.

English descriptors

KwdEn :
- Brain (diagnostic imaging), Brain (metabolism), Cerebrovascular disease, Dihydroxyphenylalanine (analogs & derivatives), Disease Progression, Dopamine, Dopamine (metabolism), Emission tomography, Female, Fluorine Radioisotopes, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Parkinson disease, Tomography, Emission-Computed, Turnover.
MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- diagnostic imaging : Brain, Parkinson Disease.
- metabolism : Brain, Dopamine, Parkinson Disease.
- Disease Progression, Female, Fluorine Radioisotopes, Humans, Male, Middle Aged, Tomography, Emission-Computed.

Abstract

An increase in dopamine turnover has been shown to occur early in Parkinson's disease (PD). This study investigated changes of dopamine turnover as a function of PD duration using the effective distribution volume (EDV) for dopamine, determined by positron emission tomography with 6-[¹⁸F]-fluoro-L-dopa, and compared them with changes in dopamine synthesis and storage ability, quantified with the fluorodopa uptake rate constant K_i. Six healthy subjects, 9 early PD patients (PD1), and 13 advanced PD patients (PD2) participated in the study. In the caudate, the K_i and EDV for PD1 were not significantly different from the normal values, whereas in the putamen K_i was 63% of normal and EDV was only 35%. Between PD1 and PD2 the decline in EDV was higher than that for K_i (caudate 44% and putamen 46% for EDV vs. 21% and 34%, respectively, for K_i). Turnover was higher in the caudate than the putamen in controls, whereas the PD patients exhibited the reverse pattern. This comparison of changes in K_i and EDV as a function of disease progression indicates that a relatively slower decrease in dopamine synthesis and a relatively faster increase in turnover in early disease likely act as compensatory mechanisms, and that the clinical onset of PD reflects a global failure of dopaminergic compensatory mechanisms.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">An increase in dopamine turnover has been shown to occur early in Parkinson's disease (PD). This study investigated changes of dopamine turnover as a function of PD duration using the effective distribution volume (EDV) for dopamine, determined by positron emission tomography with 6-[<sup>18</sup>
F]-fluoro-L-dopa, and compared them with changes in dopamine synthesis and storage ability, quantified with the fluorodopa uptake rate constant K<sub>i</sub>
. Six healthy subjects, 9 early PD patients (PD1), and 13 advanced PD patients (PD2) participated in the study. In the caudate, the K<sub>i</sub>
 and EDV for PD1 were not significantly different from the normal values, whereas in the putamen K<sub>i</sub>
 was 63% of normal and EDV was only 35%. Between PD1 and PD2 the decline in EDV was higher than that for K<sub>i</sub>
 (caudate 44% and putamen 46% for EDV vs. 21% and 34%, respectively, for K<sub>i</sub>
). Turnover was higher in the caudate than the putamen in controls, whereas the PD patients exhibited the reverse pattern. This comparison of changes in K<sub>i</sub>
 and EDV as a function of disease progression indicates that a relatively slower decrease in dopamine synthesis and a relatively faster increase in turnover in early disease likely act as compensatory mechanisms, and that the clinical onset of PD reflects a global failure of dopaminergic compensatory mechanisms.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: Their relation to disease-compensatory mechanisms

Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: Their relation to disease-compensatory mechanisms

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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